Credit cards (Amex, Visa and Master Card) are accepted in most of the hotels and restaurants here. However it is not a very well developed system, hence it is also advised to carry a good amount of cash with you as well, so as to avoid any troublesome situation. You may exchange you credit card for cash at some hotels, e.g. Uzbekistan, Radisson Blu, Intercontinental, Markaziy, etc. but this is upon actual availability of local currency (Soum) in the ATM at the time of withdrawal.